Derived from the amino acid known as L-Arginine, Agmatine sulfate is a biogenic amine. After a process of decarboxylation of the amino acid L-Arginine, the compound that results is Agmatine sulfate that is stored in the brain and released when neurons become activated.

Agmatine sulfate has actions that are different from those of L-Arginine and can be used as a supplement to drug addiction, neuropathic pain, stroke protection and cognitive health. Additionally, it is also used as a neurotransmitter or a neuromodulator.

Among the activities that Agmatine sulfate has, releasing endorphins and opioid chemicals are part of them. These chemicals enhance the effects of fentanyl and morphine and increase pain killing, lower addiction, and reduced tolerance.


Benefits of Agmatine sulfate

Though it may appear to have the same effects as Arginine, it has greater potency. Due to its Nootropic effect, it helps people attain mental edge when doing physical training. You have a healthy mood and no anxiety at all.

Agmatine sulfate acts as an anti-oxidant. This benefits you by limiting glutamate activity and reduces the excitement of the brain. Due to this, you are able to prevent excitotoxicity that occurs when one uses too much Nootropic supplements. Removal of these toxins ensures that your brain is in a better state; consequently, so is your body. This drug also has athletic effects. It enhances and improves insulin response in the body.

This helps you have a harder, leaner body that is muscular. For overall body composition, there is increased production of Growth hormones and Luteinizing hormone when you use Agmatine sulfate. This drug also helps increase energy for better pumps when doing weight training by regulating Nitric Oxide in the body, Agmatine sulfate also acts as an analgesic. This means that it helps in pain relief. It also releases various types of endorphins and natural opioids. It can be used with marijuana and morphine to create a synergistic effect. Therefore, it can be used therapeutically to treat addictions.


The accepted dosage on a daily basis for Agmatine sulfate is 250g and 2.5 grams. However, there is a need for care when taking high doses. When used as a supplement, use it 30-45minutes before you do your workout. For those who use the drug for analgesic purposes or benefits to the mind, consult your doctor on how to take small administrations throughout the day.

Side effects

Studies done have shown that there are no side effects when using Agmatine sulfate regardless of the dose. Nonetheless, this does not mean that you start taking the supplement without talking to a drug counselor or a health care provider. Your dose should be determined by the reasons you are taking the drug.